Sharing Tools and Resources
Laboratory for Cancer Research
The Frederick National Laboratory for Cancer Research (FNLCR),
formerly NCI-Frederick, is home to many talented scientific researchers. The
STAR page at the Scientific Library is dedicated to them, and to the scientific
resources they have created, and is open to all FNLCR researchers who wish to
share the resources they have developed with the rest of FNLCR, as well as with
a larger, world-wide community of researchers, in the spirit of collaboration
that moves research forward and makes breakthroughs more likely to happen.
Please contact the Scientific Library for more information on how you can have
your resource represented on the STAR page.
We invite all STAR participants to link back to this webpage from
their resource to encourage ease of access to all these valuable resources.
Current Research Initiatives:
AVIA-Automated Variation and
Impact Analysis – AVIA is a web based resource for variant detection
(Sanger Sequencing) as well as impact analysis. This resource allows users to
interrogate specific genomic coordinates and determine the impact of the
mutation based on public information as well as user specified data from their
own experiments. Article
DataBase network – bioDBnet is an application integrating a wide
range of biological databases and providing an easy interface for researchers
to annotate and convert between various biological identifiers like genes to
pathways, mouse genes to human genes, SNPs to genes.
– CyloFold addresses the single-sequence RNA structure prediction problem
with pseudoknots. Article
Resource – DAVID (the Database for Annotation, Visualization and
Integrated Discovery) is a free online bioinformatics resource aimed to provide
functional interpretation of large lists of genes derived from genomic studies,
e.g. microarray and proteomics studies.
– KNetFold is the method of choice for RNA secondary structure prediction
if an alignment of RNA sequences is available.
– NanoFolder predicts the RNA secondary structure of a set of RNA strands
(possibly forming a complex).
@ NIH Fellows and Young Investigators (NCI FYI) Mobile App – The NCI
FYI mobile application offers a centralized source of available resources to
fellows and trainees working on the NIH main Campus in Bethesda, MD, off campus
in the surrounding area in Rockville, MD and Frederick, MD.
@ NIH Summer Interns Program (NCI SIP) Mobile App – The NCI SIP
mobile application provides summer interns a source for accessing activities
and resources available during their eight week tenure working at the NIH main
campus in Bethesda, MD, off campus in the surrounding area in Rockville, MD and
NCI CADD Group's Chemical
Structure Web Services – Web services allowing you to (a) find
chemical structures and information about where these molecules occur in the
~140 small molecule databases aggregated by the NCI CADD Group into a
collection of approx. 120 million chemical structure records representing about
approx. 70 million unique chemical structures, (b) convert your chemical
structures from one format into another, and (c) integrate these resources into
your own web site.
NCI Frederick in Print
– The NCI-Frederick-in-Print database is a collection of citations for
publications authored by employees and contractors of the National Cancer
Institute at Frederick from 1997 through the present.
Oxide Database – See also "Tools for studying the Biological Effects
of Nitric Oxide (NO) and Nitroxyl (HNO)".
non-B DB, a database of
predicted non-B DNA-forming motifs in mammalian genomes and the non-B DNA Motif
Search Tool (nBMST) – non-B DB web resource allows users to query
pre-computed non-B DNA motifs in several mammalian species and to submit their
favorite DNA sequences for custom non-B DNA search.
Immunohistochemistry Database – This database features 250 different
immunohistochemical techniques optimized in mouse tissues. It may be searched
by Antibody, Manufacturer, and Fixative.
– RNA2D3D is a graphical, interactive system for rapid conversion of RNA
2D structures to 3D models and interactive 3D model refinement.
– StructureLab is a software workbench for prediction and analysis of 2D
RNA structures. It provides interactive GUI-based data mining of the solution
spaces produced by the secondary structure prediction programs.
Studying the Biological Effects of Nitric Oxide (NO) and Nitroxyl (HNO)
– Caged nitric oxide (NO) prodrugs as research tools and for use in
designing advances in clinical practice.
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