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Selective Bibliography of Dr. Stuart F. J. Le Grice
HIV Drug Resistance Program, NCI

"Reverse Transcriptase-associated Ribonuclease H: The Tail that Wags the Dog"
Wednesday, April 2, 2008


1. Yi-Brunozzi HY, Brinson RG, Brabazon DM, Lener D, Le Grice SF, Marino JP
High-Resolution NMR Analysis of the Conformations of Native and Base Analog Substituted Retroviral and LTR-Retrotransposon PPT Primers
CHEMISTRY & BIOLOGY 15 (3):254-262 Mar 2008

2. Marchand C, Beutler JA, Wamiru A, Budihas S, Mollmann U, Heinisch L, Mellors JW, Le Grice SF, Pommier Y
Madurahydroxylactone Derivatives as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and RNase H
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 52 (1):361-364 Jan 2008

3. Takada K, Bermingham A, O'Keefe BR, Wamiru A, Beutler JA, Le Grice SF, Lloyd J, Gustafson KR, McMahon JB
An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis
JOURNAL OF NATURAL PRODUCTS 70 (10):1647-1649 Oct 2007

4. Dat NT, Bae K, Wamiru A, McMahon JB, Le Grice SF, Bona M, Beutler JA, Kim YH
A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H
JOURNAL OF NATURAL PRODUCTS 70 (5):839-841 May 2007

5. Klarmann GJ, Eisenhauer BM, Zhang Y, Gotte M, Pata JD, Chatterjee DK, Hecht SM, Le Grice SF
Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids
BIOCHEMISTRY 46 (8):2118-2126 Feb 27 2007

6. Rausch JW, Le Grice SF
Exploiting structurally diverse nucleoside analogs as probes of reverse transcription complexes
CURRENT HIV RESEARCH 5 (1):11-22 Jan 2007

7. Rausch JW, Le Grice SF
Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis
NUCLEIC ACIDS RESEARCH 35 (1):256-268 2007

8. Dash C, Fisher TS, Prasad VR, Le Grice SF
Examining interactions of HIV-1 reverse transcriptase with single-stranded template nucleotides by nucleoside analog interference
JOURNAL OF BIOLOGICAL CHEMISTRY 281 (38):27873-27881 Sep 22 2006

9. Bampi C, Bibillo A, Wendeler M, Divita G, Gorelick RJ, Le Grice SF, Darlix JL
Nucleotide excision repair and template-independent addition by HIV-1 reverse transcriptase in the presence of nucleocapsid protein
JOURNAL OF BIOLOGICAL CHEMISTRY 281 (17):11736-11743 Apr 28 2006

10. Mandal D, Dash C, Le Grice SF, Prasad VR
Analysis of HIV-1 replication block due to substitutions at F61 residue of reverse transcriptase reveals additional defects involving the RNase H function
NUCLEIC ACIDS RESEARCH 34 (10):2853-2863 2006



Created 3/26/08

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